- The Immune System. In mice, the age dependent involution of the thymus gland was accompanied by a dramatic decline in CoQ10-dependant enzyme activity.
- Cell Regulation. CoQ10 can stimulate cell growth in vitro. CoQ10 may stimulate plasma membrane electron transfer and may be involved in the control signal transduction in cells.
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A Nutritional Support For Energy Protection. CoEnzyme Q10 ( CoQ10 ), also called ubiquinone, plays a key role in energy production from the oxidation of fat, carbohydrate and amino acids by mitochondria. As these fuels funnel into the Citric Acid Cycle to be oxidized to carbon dioxide, electrons are transferred in the mitochondrial electron transport CoQ10 in order to generate ATP. Without adequate CoQ10, energy production is reduced and cell function is compromised. Heart and skeletal muscle are particularly dependent on CoQ10.
The myocardium derives 80% of its energy from ATP generated by the mitochondrial oxidation of fatty acids. Studies show that decreased levels of CoQ10 in serum and in myocardial tissue are highly correlated with decreased cardiac output. Impaired myocardial energy production would be expected to diminish myocardial function. Conditions linked to low tissue oxygen, such as cardiac ischemia, as well as conditions related to infection, inflammation and stress correlate with reduced tissue and serum CoQ10 levels.
The body readily converts CoQ10 to a reduced form, called ubiquinol, which predominates when there is a net generation of ATP in the cell. Recent research indicated that Coenzyme Q10 is also localized in the endoplasmic reticulum, the Golgi complex and plasma membranes of cells where it may function as widespread antioxidant. CoQ10 scavenges free radicals to protect mitochondrial membrane lipids, and possibly regenerates beta vitamin E after reaction with lipid radicals. The oxidation of isolated LDL from healthy individuals can be reduced by the addition of ubiquinol. This protection also occurs with lycopene, beta carotene and vitamin E. In vitro studies indicated that ubiquinol also protects against the oxidation of mitochondrial DNA and protein. When supplemented daily with CoQ10 healthy volunteers decreased the level of malondialdehyde produced with the consumption of polyunsaturated fatty acids.
Biotics Research was the first to introduce CoEnzyme Q10 into the U.S. Supplment Industry is a lipid. In the intestinal tract dietary CoQ10 is normally emulsified by bile prior to absorption where uptake follows the usual route for fat-soluble vitamins. Most seems to be incorporated into chylomicrons and exported through the lymphatic system.
Other Possible Roles of CoEnzyme Q10
Oral supplementation with powdered CoQ10 in the range of 90 to 150 mg daily has been shown to elevate serum CoQ10 levels 2 to 3 fold. However, many factors influence the efficiency of absorption, including digestion, intestinal integrity and liver function.
CoEnzyme Q10 from Biotics is Emulsified.
In an effort to maximize the uptake of lipophalic vitamins and cofactors, Biotics Research developed technology to produce stable emulsions without the use of detergent like-substances commonly used to form micelles. Based on a double blind clinical study, ingestion of 30mg of Biotics emulsified CoQ10 for 4 weeks increased plasma CoQ10 levels by 210%, equivalent to 90-100 mg of dry CoQ10. Furthemore, dry CoQ10 powder increased serum levels in only 57% of subjects, while the Biotics Research emlusified CoQ10 produces increased serum CoQ10 levels in 80% of the subjects.
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