Osteo-B Plus™
Comprehensive Nutritional Support for Bone Health

Nearly 30% of American women will develop osteoporosis.

Bone is a dynamic tissue that requires adequate nutrition for maintenance and growth. Because of the balance between bone building, performed by cells called osteoblasts, and bone dissolution, carried out by cells called osteoclasts, bone growth and maintenance possess distinctive nutritional needs. Key nutrient deficiencies increase the risk of osteoporosis.

The importance of calcium has long been recognized in bone health. However, as important as calcium is to bone health, only 25% of women with osteoporosis are calcium deficient. New evidence clearly supports the view that multiple nutrients are essential to nurture the skeletal system and I have found that Osteo-B Plus™ provides these essential nutrients by preserving existing mineral mass and protein matrix as well as supporting bone repair mechanisms.

Osteo-B Plus™ Supplies:

Calcium: Supplementation may help prevent bone loss in calcium-deficient people. Those having demineralized bones may have difficulty absorbing calcium due to low stomach acid production. Some forms of calcium are poorly absorbed. Calcium as calcium citrate, the most absorbable form of calcium, especially for those with low stomach acid production is found in Osteo-B Plus™ .

Magnesium: In addition to being a co-factor for key enzymes in bone, including alkaline phosphatase used in remodeling, magnesium is also a cofactor in enzymes involved in converting vitamin D to its hormone form. Abnormal mineralization has been correlated with osteoporotic women found to be low in magnesium. Magnesium supplementation along with calcium may increase bone mineralization.

Boron: Boron affects the actions of parathormone, estrogen and cholecalciferol. A combined deficiency of magnesium and boron causes detrimental changes in bone in animals. In human subjects, boron deprivation lowered plasma calcitonin levels, increased total plasma levels and increased excretion of calcium. Normalization of steroidal hormone levels, which is closely related to bone mineralization, was observed in postmenopausal women supplemented with 3 mg. of boron daily.

Manganese: Deficiency can lead to bone malformation and thinning. Manganese is required for the synthesis of connective tissue glycosaminoglycans (chondroitin sulfates) that form the matrix upon which mineral deposition occurs. Osteoporotic women were found to have only 25% of the manganese levels observed in control groups.

Cooper: Deficiency may lead to abnormal bone deposition. Collagen is laid down prior to mineralization in order to establish a protein matrix for mineralization. Copper is a cofactor for lysyl oxidase, the enzyme that forms cross links between collagen in connective tissue. The typical diet supplies as little as 50% of the recommended daily intake of copper.

Zinc: Low levels of serum zinc and bone zinc were observed in osteoporotic patients. Zinc supports bone formation by enhancing the action of vitamin D, and is a cofactor for alkaline phosphatase. Typical diets contain less than the desired amount of zinc.

Vitamin D: Vitamin D is the primary factor in regulation of calcium absorption by the intestine. Administration of the hormone derived from vitamin D, cholecalciferol, significantly decreased the rate of bone loss and increased calcium uptake. Low levels of vitamin D are common in elderly women. Deficiencies of vitamin D can lead to calcium deficiencies, leading to soft bones (osteomalacia).

Vitamin K: The synthesis of osteocalcin, the bone protein that attracts calcium to bone tissue, requires vitamin K as a cofactor. Administration of vitamin K to individuals with osteoporosis reduced urinary excretion of calcium by 18-50%. Factors limiting vitamin K uptake include long term usage of antibiotics, vitamin K antagonists, such as warfarin, and malabsorption of fat and fat-soluble vitamins due to maldigestion.

B Complex Vitamins: B vitamins function as coenzymes in metabolic pathways to provide energy and building blocks from foods. Shortages impair healing and repair by connective tissue, including bone turnover. B complex vitamins work as a team; all should be present in appropriated amounts for optimal functioning. For example, elevated blood homocysteine is linked to osteoporosis; homocysteine interferes with collagen cross linking. Folate and B6 promote the conversion of homocysteine to simple amino acids. B6 also participated in collagen cross linking.

Vitamin C: Enzymes that form hydroxyproline and hydroxylysine require vitamin C. These hydroxyamino acids form cross-links with collagen and elastin in mature connective tissue and matrix. Twenty percent of elderly women were found to be deficient in vitamin C, even though they consumed RDA amounts (60 mg) daily.

Purified Chondroitin Sulfates: Chondroitin sulfates represent glycosaminoglycans (GAG), these polysaccharides are found in connective tissue such as cartilage. Preformed GAG can stimulate chondroitin sulfate synthesis. Osteo-B Plus supplies highly purified chondroitin sulfates, up to 90% of which can be readily absorbed.

Saccarum Officinarum Extract: This ingredient is an especially rich source of silicon,. Silicon is required for structural integrity of connective tissue and bone strength. It is believed to function as a cross-linking agent to strengthen connective tissue.

This formula is available on the products order page or just click here.

To read previously featured articles click here.

You Can Contact Us In Any Of The Following Ways: Call us at 1-800-276-3409. We will gladly answer any of your questions. Send Us E-Mail and follow the instructions given. Another way to contact Dr. Locke is through our Guest Book.